Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Methyl Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991440 | 0.78 | HDAC8 (0.53) | HDAC8KDM4EALDH1A1MAPTCTDSP1 | |
| Iodide SCHEMBL997529 | 0.71 | HDAC8 (0.95) | HDAC8KDM4EALDH1A1MAPTCTDSP1 | |
| SCHEMBL29961324 | 0.69 | — | — | |
| SCHEMBL589251 | 0.69 | — | — | |
| SCHEMBL10881551 | 0.68 | HDAC8 (0.46) | HDAC8KDM4EALDH1A1MAPTCTDSP1 | |
| Methyl Alcohol SCHEMBL10936101 | 0.67 | KDM4A (0.48) | HDAC8KDM4EALDH1A1MAPTCTDSP1 | |
| Fluoride Ion SCHEMBL7937290 | 0.67 | HDAC8 (0.95) | HDAC8KDM4EALDH1A1MAPTCTDSP1 | |
| Water SCHEMBL9445012 | 0.67 | HDAC8 (0.95) | HDAC8KDM4EALDH1A1MAPTCTDSP1 | |
| Bromide SCHEMBL29392397 | 0.67 | HDAC8 (0.95) | HDAC8KDM4EALDH1A1MAPTCTDSP1 | |
| Hydrochloric Acid SCHEMBL461720 | 0.67 | HDAC8 (0.95) | HDAC8KDM4EALDH1A1MAPTCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4548893-A | NEGATIVE WORKING, VINYL POLYMER HAVING AROMATIC QUATERNIZED NITROG | GTE LABORATORIES INCORPORATED (US) | 1985-10-22 | — | — | US | disclosed |