Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9554357 | 0.79 | SMN1; SMN2 (0.52) | CYP3A4HIF1ASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL5051285 | 0.74 | SMN1; SMN2 (0.41) | CYP3A4HIF1ASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL10942034 | 0.71 | NPC1 (0.36) | CYP3A4ALOX15TSHRSLC22A2SLC22A1 | |
| SCHEMBL10938259 | 0.70 | CYP3A4 (0.47) | CYP3A4ALOX15TSHRSLC22A2SLC22A1 | |
| SCHEMBL27515246 | 0.70 | SMN1; SMN2 (0.48) | CYP3A4TSHRHIF1ASMN1; SMN2KMT2A | |
| SCHEMBL9555278 | 0.69 | PTPN1 (0.47) | CYP3A4TSHRHIF1ASMN1; SMN2MEN1 | |
| SCHEMBL6576298 | 0.69 | KCNH2 (0.61) | CYP3A4ALOX15TSHRSLC22A2SLC22A1 | |
| SCHEMBL11532046 | 0.69 | CYP2D6 (0.46) | CYP3A4ALOX15TSHRSLC22A2SLC22A1 | |
| SCHEMBL11599547 | 0.69 | CYP2D6 (0.68) | CYP3A4ALOX15TSHRSLC22A2SLC22A1 | |
| SCHEMBL28561877 | 0.68 | SMN1; SMN2 (0.43) | CYP3A4ALOX15TDP1HIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4554353-A | 2,5-Pyrrolidinedione derivatives useful as antiarrhythmic agents | G. D. SEARLE & CO. (US) | 1985-11-19 | — | — | US | disclosed |