Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | ARG1 | P05089 | 1/20 | 0.38 |
| ▸ | ARG2 | P78540 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27515246 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2HIF1ACYP1A2CYP1A1CYP1B1 | |
| SCHEMBL5051285 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2HIF1ACYP1A2CYP1A1CYP1B1 | |
| SCHEMBL28561877 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2HIF1ACYP1A2CYP1A1CYP1B1 | |
| SCHEMBL9555278 | 0.80 | PTPN1 (0.47) | SMN1; SMN2HIF1ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10938263 | 0.79 | CYP3A4 (0.42) | SMN1; SMN2HIF1ACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL23723015 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1ACYP1A2CYP1A1CYP1B1 | |
| SCHEMBL2033607 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1ACYP1A2CYP1A1CYP1B1 | |
| SCHEMBL2030784 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1ACYP1A2CYP1A1CYP1B1 | |
| SCHEMBL7942748 | 0.78 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1TAAR1MMP8 | |
| SCHEMBL1750351 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2HIF1ACYP1A2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-5190922-A | Antiinflammatory | ABBOTT LABORATORIES (US) | 1993-03-02 | — | — | US | disclosed |
| WO-1992021361-A1 | TERMINALLY MODIFIED TRI-, TETRA- AND PENTAPEPTIDE ANAPHYLATOXIN RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 1992-12-10 | — | — | WO | disclosed |
| US-4444928-A | NONHYDROLYZING LIGHT STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1984-04-24 | — | — | US | disclosed |