Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 9/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936759 | 0.89 | PTGS2 (0.61) | PTGS2MAPK14PTGS1BRD4BRD2 | |
| Flosulide SCHEMBL29454969 | 0.81 | PTGS2 (1.00) | PTGS2MAPK14PTGS1BRD4 | |
| Flosulide SCHEMBL195509 | 0.81 | PTGS2 (1.00) | PTGS2MAPK14PTGS1BRD4 | |
| Flosulide SCHEMBL29383035 | 0.81 | PTGS2 (1.00) | PTGS2MAPK14PTGS1BRD4 | |
| SCHEMBL10942403 | 0.79 | PTGS2 (0.62) | PTGS2MAPK14PTGS1BRD4 | |
| SCHEMBL14462977 | 0.77 | PTGS2 (0.80) | PTGS2MAPK14PTGS1BRD4 | |
| SCHEMBL10939372 | 0.74 | PTGS2 (0.69) | PTGS2MAPK14PTGS1BRD4 | |
| SCHEMBL11150103 | 0.72 | HSPB1 (0.57) | PTGS2MAPK14 | |
| SCHEMBL10937966 | 0.72 | PTGS2 (0.63) | PTGS2MAPK14PTGS1BRD4 | |
| SCHEMBL10940467 | 0.72 | PTGS2 (0.42) | PTGS2MAPK14PTGS1BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0056956-B1 | INDANYL DERIVATIVES THEIR PREPARATION AND THEIR USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-11-27 | — | — | EP | disclosed |
| US-4375479-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-03-01 | — | — | US | disclosed |
| EP-0056956-A2 | Indanyl derivatives their preparation and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-08-04 | — | — | EP | disclosed |