Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 10/20 | 0.40 |
| ▸ | CA12 | O43570 | 9/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.40 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10942420 | 0.88 | ACE (0.40) | ACEKMT2ACA9CA12CA2 | |
| SCHEMBL11066115 | 0.84 | ACE (0.71) | ACEKMT2ALMNAALDH1A1FFAR2 | |
| SCHEMBL10938815 | 0.84 | ACE (0.71) | ACEKMT2ALMNAALDH1A1FFAR2 | |
| SCHEMBL11293550 | 0.83 | ACE (0.51) | ACECA9CA12CA2RAB9A | |
| SCHEMBL10939290 | 0.83 | ACE (0.51) | ACECA9CA12CA2RAB9A | |
| SCHEMBL11300797 | 0.82 | CA9 (0.43) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| SCHEMBL10939281 | 0.80 | ACE (0.49) | ACECA9CA12CA2RAB9A | |
| SCHEMBL10968295 | 0.79 | ACE (0.71) | ACEKMT2ALMNAALDH1A1FFAR2 | |
| SCHEMBL10939317 | 0.78 | ACE (0.55) | ACEKMT2ALMNAFFAR2 | |
| SCHEMBL11184392 | 0.78 | ACE (0.69) | ACEKMT2ALMNAALDH1A1FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067885-B1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-09-04 | — | — | EP | claimed |
| US-4464371-A | HYPOTENSIVE AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-07 | — | — | US | claimed |
| EP-0067885-B1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-09-04 | — | — | EP | disclosed |
| US-4464371-A | HYPOTENSIVE AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| EP-0067885-A1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-12-29 | — | — | EP | disclosed |