Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10942225 | 0.85 | ALDH1A1 (0.60) | NPC1RAB9AALDH1A1GAANR4A2 | |
| SCHEMBL10940167 | 0.83 | HTT (0.68) | HTTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL10946156 | 0.83 | NPC1 (0.61) | HTTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL10945693 | 0.80 | MAPK7 (0.50) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL608814 | 0.76 | ABL1 (0.68) | NPC1RAB9ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL21802604 | 0.75 | MAP2K1 (0.45) | HTTRAB9ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL10937651 | 0.75 | ALDH1A1 (0.62) | HTTCYP1A2CYP2C19ALDH1A1GAA | |
| SCHEMBL29190963 | 0.74 | ALDH1A1 (0.70) | HTTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL29191090 | 0.74 | ALDH1A1 (0.68) | HTTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL10937230 | 0.74 | MAPK14 (0.58) | ALDH1A1GAALMNABAZ2BBAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |