Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | FFAR2 | O15552 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11385050 | 0.96 | ACE (0.61) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL11257852 | 0.89 | ACE (0.55) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL683641 | 0.88 | ACE (0.73) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL8870565 | 0.84 | HSD17B10 (0.57) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL8871013 | 0.84 | HSD17B10 (0.57) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL10944184 | 0.84 | ACE (0.80) | ACEHSD17B10FFAR2POLBALDH1A1 | |
| SCHEMBL11061437 | 0.82 | KMT2A (0.58) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL13091650 | 0.81 | HSD17B10 (0.54) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL13101399 | 0.81 | HSD17B10 (0.54) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL10943590 | 0.81 | GAA (0.50) | ACEHSD17B10FFAR2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |