Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ACE | P12821 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FFAR2 | O15552 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257852 | 0.88 | ACE (0.55) | KMT2AACEHSD17B10FFAR2POLB | |
| SCHEMBL10938815 | 0.86 | ACE (0.71) | KMT2AACEFFAR2POLBALDH1A1 | |
| SCHEMBL11066115 | 0.86 | ACE (0.71) | KMT2AACEFFAR2POLBALDH1A1 | |
| SCHEMBL11385050 | 0.86 | ACE (0.61) | KMT2AACEHSD17B10FFAR2POLB | |
| SCHEMBL11067695 | 0.85 | KMT2A (0.53) | KMT2AACEHSD17B10FFAR2POLB | |
| SCHEMBL11071522 | 0.84 | KMT2A (0.46) | KMT2AACEHSD17B10FFAR2ALDH1A1 | |
| SCHEMBL10939993 | 0.82 | ACE (0.57) | KMT2AACEHSD17B10FFAR2POLB | |
| SCHEMBL683641 | 0.81 | ACE (0.73) | ACEHSD17B10FFAR2POLBGAA | |
| SCHEMBL11110326 | 0.80 | ACE (0.51) | KMT2AACEFFAR2LMNA | |
| SCHEMBL11192009 | 0.80 | KMT2A (0.57) | KMT2AACEFFAR2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4430344-A | Antihypertensive 4-thiazolidinecarboxylic acids | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-02-07 | — | — | US | disclosed |
| US-4423054-A | Antihypertensive 4-thiazolidinecarboxylic acids (substituted alkyl derivatives) | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| US-4386096-A | ANGIOTENSIN-CONVERTING ENZYME INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-05-31 | — | — | US | disclosed |
| US-4356183-A | ENZYME INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-10-26 | — | — | US | disclosed |