SCHEMBL10941024

SCHEMBL10941024

O=S(=O)(Cl)c1ccccc1Oc1ccc(C(F)(F)F)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.45
MAPT P10636 1/20 0.45
MCL1 Q07820 2/20 0.45
KMT2A Q03164 2/20 0.45
MRGPRX4 Q96LA9 5/20 0.44
FFAR1 O14842 2/20 0.43
EPAS1 Q99814 1/20 0.43
CCR1 P32246 1/20 0.42
CCR2 P41597 1/20 0.42
SCN8A Q9UQD0 1/20 0.41
SCN10A Q9Y5Y9 1/20 0.41
MEN1 O00255 1/20 0.40
TTR P02766 1/20 0.40
PPOX P50336 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
ESRRA P11474 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10940298 0.88 MRGPRX4 (0.52) LMNAMAPTMCL1KMT2AMRGPRX4
SCHEMBL10932002 0.86 MRGPRX4 (0.49) MCL1KMT2AMRGPRX4FFAR1MEN1
SCHEMBL10943802 0.85 LMNA (0.49) LMNAMAPTMCL1KMT2AMRGPRX4
SCHEMBL11095171 0.83 KMT2A (0.51) KMT2AMRGPRX4FFAR1SCN8ASCN10A
SCHEMBL28395070 0.82 KMT2A (0.58) LMNAMAPTKMT2AMRGPRX4FFAR1
SCHEMBL10707742 0.80 FFAR1 (0.54) KMT2AMRGPRX4FFAR1MEN1TTR
SCHEMBL11193770 0.80 FFAR1 (0.47) LMNAMAPTKMT2AMRGPRX4FFAR1
SCHEMBL3870764 0.80 CA1 (0.44) MCL1KMT2AEPAS1
SCHEMBL7803938 0.77 ESRRA (0.53) MAPTKMT2AMRGPRX4FFAR1TTR
SCHEMBL9373632 0.77 CYP1A2 (0.62) LMNAMAPTKMT2AMRGPRX4FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4540824-A Diphenyl sulfide compounds useful as intermediates in the production of diphenyl sulfone compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-09-10 US disclosed
US-4486223-A PREEMERGENCE AND POSTEMERGENCE HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-04 US disclosed
US-4486604-A PRE-AND POSTEMERGENCE HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-04 US disclosed
EP-0090870-A1 Diphenyl sulfone compounds, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-10-12 EP disclosed
US-4374662-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-02-22 US disclosed