SCHEMBL10932002

SCHEMBL10932002

O=S(=O)(Cl)c1c(Oc2ccc(C(F)(F)F)cc2Cl)cccc1Oc1ccc(C(F)(F)F)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 11/20 0.49
FFAR1 O14842 2/20 0.45
MCL1 Q07820 1/20 0.45
MEN1 O00255 1/20 0.42
TTR P02766 1/20 0.42
PPOX P50336 1/20 0.42
KMT2A Q03164 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10941024 0.86 LMNA (0.45) MRGPRX4FFAR1MCL1MEN1TTR
SCHEMBL11095171 0.82 KMT2A (0.51) MRGPRX4FFAR1MEN1TTRPPOX
SCHEMBL10707742 0.82 FFAR1 (0.54) MRGPRX4FFAR1MEN1TTRPPOX
SCHEMBL28395070 0.81 KMT2A (0.58) MRGPRX4FFAR1MEN1TTRPPOX
SCHEMBL10940298 0.79 MRGPRX4 (0.52) MRGPRX4FFAR1MCL1MEN1TTR
SCHEMBL11193770 0.79 FFAR1 (0.47) MRGPRX4FFAR1MEN1TTRPPOX
SCHEMBL10943802 0.77 LMNA (0.49) MRGPRX4FFAR1MCL1KMT2A
SCHEMBL10538095 0.76 NPSR1 (0.57) MRGPRX4FFAR1MEN1TTRPPOX
SCHEMBL9373632 0.76 CYP1A2 (0.62) MRGPRX4FFAR1MEN1TTRPPOX
SCHEMBL7803938 0.76 ESRRA (0.53) MRGPRX4FFAR1TTRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-60087257-A None JP disclosed
JP-S6087257-A PRODUCTION OF DIPHENYL SULFONE DERIVATIVE SUMITOMO CHEM CO LTD 1985-05-16 JP disclosed