Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361785 | 0.93 | ACE (0.59) | ACEACE2TSHR | |
| SCHEMBL7361782 | 0.93 | ACE (0.59) | ACEACE2TSHR | |
| SCHEMBL7330602 | 0.86 | ACE (0.66) | ACEACE2TSHR | |
| SCHEMBL11004279 | 0.85 | ACE (0.61) | ACEACE2 | |
| SCHEMBL10944258 | 0.85 | ACE (0.61) | ACEACE2 | |
| SCHEMBL10679400 | 0.84 | ACE (0.66) | ACEACE2TSHR | |
| SCHEMBL5496422 | 0.82 | ACE (0.69) | ACEACE2 | |
| SCHEMBL27890165 | 0.79 | ACE (0.73) | ACEACE2 | |
| SCHEMBL27890164 | 0.79 | ACE (0.73) | ACEACE2 | |
| SCHEMBL31621499 | 0.78 | ACE (0.64) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558150-A | ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0158947-A2 | Amino thiol dipeptides | E.R. Squibb & Sons, Inc. (US) | 1985-10-23 | — | — | EP | disclosed |
| US-4500518-A | ANALGESICS, HYPTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-19 | — | — | US | disclosed |