Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 0.59 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361782 | 1.00 | ACE (0.59) | ACEACE2TSHR | |
| SCHEMBL10942007 | 0.93 | ACE (0.58) | ACEACE2TSHR | |
| SCHEMBL7330602 | 0.87 | ACE (0.66) | ACEACE2TSHR | |
| SCHEMBL10679400 | 0.85 | ACE (0.66) | ACEACE2TSHR | |
| SCHEMBL7365884 | 0.84 | ACE (0.61) | ACEACE2 | |
| SCHEMBL7361792 | 0.84 | ACE (0.61) | ACEACE2 | |
| SCHEMBL5496422 | 0.82 | ACE (0.69) | ACEACE2 | |
| SCHEMBL7367708 | 0.81 | ACE (0.47) | ACEACE2 | |
| SCHEMBL10847172 | 0.80 | ACE (0.51) | ACEACE2 | |
| SCHEMBL27890165 | 0.80 | ACE (0.73) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4514391-A | HYPOTENSIVE AGENTS; ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1985-04-30 | — | — | US | claimed |
| EP-0132304-A2 | Hydroxy substituted peptide compounds | E.R. Squibb & Sons, Inc. (US) | 1985-01-30 | — | — | EP | claimed |
| US-4514391-A | HYPOTENSIVE AGENTS; ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1985-04-30 | — | — | US | disclosed |
| EP-0132304-A2 | Hydroxy substituted peptide compounds | E.R. Squibb & Sons, Inc. (US) | 1985-01-30 | — | — | EP | disclosed |