SCHEMBL1094244

SCHEMBL1094244

NS(=O)(=O)NN1CCOCC1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PHGDH O43175 1/20 0.46
CA12 O43570 5/20 0.42
CA7 P43166 3/20 0.42
CA14 Q9ULX7 2/20 0.42
ALDH1A1 P00352 2/20 0.42
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.37
TSHR P16473 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
CA1 P00915 8/20 0.36
CA2 P00918 8/20 0.36
CA13 Q8N1Q1 2/20 0.36
CA9 Q16790 5/20 0.36
CA3 P07451 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1645123 0.77 CA1 (0.43) CA12TSHRCA1CA2CA9
SCHEMBL16759004 0.77
SCHEMBL3886688 0.76 PHGDH (0.46) PHGDHCA12CA7CA14ALDH1A1
SCHEMBL7028490 0.76 PHGDH (0.46) PHGDHCA12CA7CA14ALDH1A1
SCHEMBL3128017 0.76 PHGDH (0.50) PHGDHCA12CA7CA14ALDH1A1
SCHEMBL1646187 0.75 CA1 (0.48) CA12CA7ALDH1A1MAPTTSHR
SCHEMBL22973711 0.74 PHGDH (0.49) PHGDHCA12CA7CA14ALDH1A1
SCHEMBL6677562 0.73 PHGDH (0.43) PHGDHCA12CA7CA14ALDH1A1
SCHEMBL6044392 0.73 PHGDH (0.40) PHGDHCA12CA7CA14ALDH1A1
SCHEMBL3631455 0.71 KDM4E (0.37) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011059459-A1 PHYSICAL CHARACTERIZATION OF OLIGONUCLEOTIDES CONJUGATES REGADO BIOSCIENCES, INC (US) 2011-05-19 WO claimed
US-6867294-B1 Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages ISIS PHARMACEUTICALS, INC. (US) 2005-03-15 US claimed
EP-0637965-B1 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES ISIS PHARMACEUTICALS INC (US) 2002-10-16 EP claimed
WO-2001040515-A1 GAPPED OLIGOMERS HAVING SITE SPECIFIC CHIRAL PHOSPHOROTHIOATE INTERNUCLEOSIDE LINKAGES ISIS PHARMACEUTICALS, INC. (US) 2001-06-07 WO claimed
US-20220025370-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE IONIS PHARMACEUTICALS, INC. (US) 2022-01-27 US disclosed
EP-3640332-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE Ionis Pharmaceuticals, Inc. (US) 2020-04-22 EP disclosed
US-20190136234-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE IONIS PHARMACEUTICALS, INC. (US) 2019-05-09 US disclosed
EP-3453761-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE Ionis Pharmaceuticals, Inc. (US) 2019-03-13 EP disclosed
EP-2751270-B1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE IONIS PHARMACEUTICALS INC (US) 2018-08-22 EP disclosed
US-10023861-B2 Oligomer-conjugate complexes and their use IONIS PHARMACEUTICALS, INC. (US) 2018-07-17 US disclosed
EP-2708541-B1 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis ISIS PHARMACEUTICALS INC (US) 2015-01-28 EP disclosed
EP-2751270-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE Isis Pharmaceuticals, Inc. (US) 2014-07-09 EP disclosed
EP-0643720-A1 BINDING COMPETENT OLIGOMERS CONTAINING 2', 5' LINKAGES GILEAD SCIENCES, INC. (US) 1995-03-22 EP disclosed
EP-0637965-A1 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES GILEAD SCIENCES, INC. (US) 1995-02-15 EP disclosed
EP-0616612-A4 NUCLEASE STABLE AND BINDING COMPETENT OLIGOMERS AND METHODS FOR THEIR USE. GILEAD SCIENCES INC (US) 1995-01-11 EP disclosed
WO-1994024144-A2 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PURINES GILEAD SCIENCES, INC. (US) 1994-10-27 WO disclosed
EP-0616612-A1 NUCLEASE STABLE AND BINDING COMPETENT OLIGOMERS AND METHODS FOR THEIR USE GILEAD SCIENCES, INC. (US) 1994-09-28 EP disclosed
WO-1993024508-A1 BINDING COMPETENT OLIGOMERS CONTAINING 2', 5' LINKAGES GILEAD SCIENCES, INC. (US) 1993-12-09 WO disclosed
WO-1993012135-A1 NUCLEASE STABLE AND BINDING COMPETENT OLIGOMERS AND METHODS FOR THEIR USE GILEAD SCIENCES, INC. (US) 1993-06-24 WO disclosed
WO-1993010820-A1 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES GILEAD SCIENCES, INC. (US) 1993-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220025370-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE DCLRE1B, NT5C3B, PAICS PHGDH 3845/4885CA12 626/4885CA7 1290/4885
US-10023861-B2 Oligomer-conjugate complexes and their use DCLRE1B, NT5C3B, PAICS PHGDH 3845/4885CA12 626/4885CA7 1290/4885
US-20190136234-A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE DCLRE1B, NT5C3B, PAICS PHGDH 3845/4885CA12 626/4885CA7 1290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.