Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11183345 | 0.88 | GAA (0.69) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL683282 | 0.86 | GAA (0.70) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL10943590 | 0.86 | GAA (0.50) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL10945275 | 0.85 | FFAR2 (0.48) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL10940821 | 0.85 | GAA (0.46) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL10943774 | 0.83 | POLB (0.45) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL10941388 | 0.81 | POLB (0.43) | GAAPOLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11000518 | 0.81 | POLB (0.43) | GAAPOLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10942643 | 0.81 | POLB (0.43) | GAAPOLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10945382 | 0.77 | ACE (0.41) | GAAPOLBRAB9ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |