Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10943458 | 0.88 | GAA (0.67) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL683282 | 0.87 | GAA (0.70) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL11186340 | 0.86 | ACE (0.50) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL11257852 | 0.86 | ACE (0.55) | GAAPOLBRAB9AALDH1A1FFAR2 | |
| SCHEMBL11188904 | 0.85 | GAA (0.51) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL11190621 | 0.85 | FFAR2 (0.48) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL11185372 | 0.84 | ACE (0.53) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL11190294 | 0.81 | ACE (0.50) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL11185141 | 0.80 | GAA (0.66) | GAAPOLBRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL11189446 | 0.79 | GAA (0.44) | GAAPOLBRAB9ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |