Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10942643 | 0.92 | POLB (0.43) | POLBGAARAB9AACESMN1; SMN2 | |
| SCHEMBL11000518 | 0.92 | POLB (0.43) | POLBGAARAB9AACESMN1; SMN2 | |
| SCHEMBL10941388 | 0.92 | POLB (0.43) | POLBGAARAB9AACESMN1; SMN2 | |
| SCHEMBL10942736 | 0.83 | POLB (0.41) | POLBGAARAB9AACESMN1; SMN2 | |
| SCHEMBL10942993 | 0.80 | L3MBTL1 (0.44) | POLBACESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL10944246 | 0.80 | L3MBTL1 (0.44) | POLBACESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL10943590 | 0.77 | GAA (0.50) | POLBGAARAB9AACESMN1; SMN2 | |
| SCHEMBL10940821 | 0.76 | GAA (0.46) | POLBGAARAB9AACESMN1; SMN2 | |
| SCHEMBL10945275 | 0.76 | FFAR2 (0.48) | POLBGAARAB9AACESMN1; SMN2 | |
| SCHEMBL10942665 | 0.76 | SMN1; SMN2 (0.45) | POLBACESMN1; SMN2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |