Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10943987 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KMT2ACYP2C19CYP1A2MAPT | |
| SCHEMBL11009653 | 0.79 | PPARG (0.49) | ALDH1A1POLBHTTKDM4EHPGD | |
| SCHEMBL11008803 | 0.79 | MRGPRX4 (0.48) | ALDH1A1CYP2D6CYP2C19CYP1A2POLB | |
| SCHEMBL10945831 | 0.78 | TAAR1 (0.51) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL11009540 | 0.78 | ALDH1A1 (0.45) | ALDH1A1CYP2D6CYP2C19CYP1A2MAPT | |
| SCHEMBL19002645 | 0.76 | MEN1 (0.66) | ALDH1A1L3MBTL1MEN1KMT2ACYP2D6 | |
| SCHEMBL10942106 | 0.76 | MAPT (0.46) | ALDH1A1MEN1KMT2ACYP1A2MAPT | |
| SCHEMBL11291865 | 0.75 | CYP19A1 (0.51) | ALDH1A1CYP2D6CYP1A2POLBCYP3A4 | |
| SCHEMBL12180472 | 0.73 | ACHE (0.60) | ALDH1A1L3MBTL1MEN1KMT2ACYP2D6 | |
| SCHEMBL11703451 | 0.73 | GAA (0.55) | ALDH1A1L3MBTL1MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4555516-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1985-11-26 | — | — | US | disclosed |
| US-4448781-A | CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |