Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.49 |
| ▸ | TMPRSS15 | P98073 | 6/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | F12 | P00748 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9861291 | 0.87 | HSD17B10 (0.71) | ALDH1A1HSD17B10HPGDKDM4EGLA | |
| SCHEMBL10941042 | 0.84 | PRSS1 (0.50) | ALDH1A1HSD17B10HPGDKDM4EGLA | |
| SCHEMBL10889487 | 0.83 | KMT2A (0.56) | ALDH1A1PRSS1TMPRSS15PARP10F12 | |
| SCHEMBL17744854 | 0.83 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HPGDKDM4EGLA | |
| Hydrochloric Acid SCHEMBL11144929 | 0.82 | KMT2A (0.55) | ALDH1A1PRSS1TMPRSS15PARP10F12 | |
| SCHEMBL6430896 | 0.82 | ALDH1A1 (0.65) | ALDH1A1HSD17B10HPGDKDM4EGLA | |
| SCHEMBL444509 | 0.81 | HSD17B10 (0.64) | ALDH1A1HSD17B10HPGDKDM4EGLA | |
| SCHEMBL10872021 | 0.81 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HPGDKDM4EGLA | |
| SCHEMBL10894177 | 0.81 | MAPT (0.62) | ALDH1A1HPGDPRSS1F12F2 | |
| SCHEMBL6890545 | 0.81 | HSD17B10 (0.72) | ALDH1A1HSD17B10HPGDKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091240-B1 | ENZYME DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1985-12-27 | — | — | EP | disclosed |
| US-4507283-A | STREPTOKINASE-HUMAN PLASMINOGEN ACTIVATOR COMPLEX BLOCKED BY A 2- OR 4-AMINOBENZOYL GROUP; ANTICOAGULANT | BEECHAM GROUP P.L.C. (GB) | 1985-03-26 | — | — | US | disclosed |
| EP-0091240-A2 | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-10-12 | — | — | EP | disclosed |