Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | IDH1 | O75874 | 2/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849720 | 0.84 | CYP11B1 (0.66) | CYP11B1CYP11B2CYP19A1POLBTDP1 | |
| SCHEMBL2509182 | 0.82 | BRD4 (0.50) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL2509183 | 0.82 | BRD4 (0.50) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL8936715 | 0.81 | CYP11B1 (0.58) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL5592277 | 0.81 | CYP11B1 (0.57) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL2508166 | 0.80 | BRD4 (0.51) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL2508169 | 0.80 | BRD4 (0.51) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL2509348 | 0.80 | JAK2 (0.52) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL2509350 | 0.80 | JAK2 (0.52) | CYP11B1CYP11B2CYP19A1BRD4POLB | |
| SCHEMBL8050377 | 0.77 | CYP11B1 (0.65) | CYP11B1CYP11B2CYP19A1BRD4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4555516-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1985-11-26 | — | — | US | disclosed |
| US-4448781-A | CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |