Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.57 |
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28198916 | 0.84 | CYP19A1 (0.62) | CYP11B1CYP19A1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL30474205 | 0.83 | CYP11B1 (0.57) | CYP11B1CYP19A1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL24500044 | 0.81 | CYP19A1 (0.58) | CYP11B1CYP19A1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL5592277 | 0.81 | CYP11B1 (0.57) | CYP11B1CYP19A1CYP11B2MAPTBRD4 | |
| SCHEMBL10945622 | 0.81 | CYP11B1 (0.57) | CYP11B1CYP19A1CYP11B2TBXAS1MAPT | |
| SCHEMBL9748629 | 0.81 | CYP19A1 (0.62) | CYP11B1CYP19A1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL2508166 | 0.80 | BRD4 (0.51) | CYP11B1CYP19A1CYP11B2TBXAS1MAPT | |
| SCHEMBL2508169 | 0.80 | BRD4 (0.51) | CYP11B1CYP19A1CYP11B2TBXAS1MAPT | |
| SCHEMBL2509182 | 0.79 | BRD4 (0.50) | CYP11B1CYP19A1CYP11B2TBXAS1MAPT | |
| SCHEMBL2509183 | 0.79 | BRD4 (0.50) | CYP11B1CYP19A1CYP11B2TBXAS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587392-A | THERAPY FOR ESTROGEN DEPENDENT DISEASES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0684235-A1 | Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-29 | — | — | EP | disclosed |
| US-4555516-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1985-11-26 | — | — | US | disclosed |
| US-4448781-A | CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |