Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10946955 | 0.90 | REN (0.57) | RENPSMB5MAPK1POLBMAPT | |
| SCHEMBL10940198 | 0.89 | REN (0.51) | RENPSMB5MAPK1POLBMAPT | |
| SCHEMBL10949155 | 0.88 | PSMB5 (0.56) | PSMB5TDP1 | |
| SCHEMBL10949165 | 0.88 | PSMB5 (0.56) | PSMB5TDP1 | |
| SCHEMBL10880715 | 0.80 | REN (0.70) | RENMAPK1POLBMAPTATM | |
| SCHEMBL9069586 | 0.79 | MME (0.55) | PSMB5TDP1 | |
| SCHEMBL9069587 | 0.79 | MME (0.55) | PSMB5TDP1 | |
| SCHEMBL10841770 | 0.78 | PSMB5 (0.56) | PSMB5 | |
| SCHEMBL6933303 | 0.77 | CAPN1 (0.65) | REN | |
| SCHEMBL10736781 | 0.77 | PSMB5 (0.59) | PSMB5TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560506-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-12-24 | — | — | US | disclosed |