SCHEMBL10948432

SCHEMBL10948432

CCCCCC1CCC(c2ccc(-c3ccc(CC)cc3[N+](=O)[O-])cc2)CC1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 13/20 0.37
CYP2C9 P11712 1/20 0.36
KAT2B Q92831 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
ABCB1 P08183 1/20 0.34
SPHK2 Q9NRA0 7/20 0.33
DGAT1 O75907 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10948427 1.00 SPHK1 (0.37) SPHK1CYP2C9KAT2BALDH1A1LMNA
SCHEMBL10944228 0.94 SPHK1 (0.34) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL10944220 0.94 SPHK1 (0.34) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL11111534 0.91 CYP2C9 (0.39) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL11111540 0.91 CYP2C9 (0.39) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL11108266 0.84 CYP2C9 (0.39) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL11108270 0.84 CYP2C9 (0.39) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL7672347 0.82 CYP2C9 (0.37) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL7672341 0.82 CYP2C9 (0.37) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL8407315 0.81 CYP2C9 (0.41) SPHK1CYP2C9SPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4545922-A Liquid crystalline fluorine-containing cyclohexylbiphenyls and dielectrics and electro-optical display elements based thereon MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1985-10-08 US disclosed
EP-0051738-B1 CYCLOHEXYL-BIPHENYL DERIVATIVES THAT CONTAIN FLUOR, DIELECTRICS CONTAINING THEM AND ELECTRO-OPTICAL INDICATING ELEMENT MERCK PATENT GmbH (DE) 1984-07-25 EP disclosed
US-4415470-A HIGH SPEED SWITCHING MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1983-11-15 US disclosed
EP-0051738-A1 Cyclohexyl-biphenyl derivatives that contain fluor, dielectrics containing them and electro-optical indicating element MERCK PATENT GmbH (DE) 1982-05-19 EP disclosed