Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10951025 | 0.95 | TSHR (0.45) | TSHRALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL10952676 | 0.79 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2GAAHPGDLMNA | |
| SCHEMBL10952060 | 0.76 | MAPT (0.41) | ALDH1A1SMN1; SMN2GAAHPGDLMNA | |
| SCHEMBL10954064 | 0.74 | MAPT (0.41) | ALDH1A1SMN1; SMN2GAAHPGDLMNA | |
| SCHEMBL21484965 | 0.71 | TSHR (0.55) | TSHRALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL1381652 | 0.71 | TSHR (0.55) | TSHRALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL1127045 | 0.70 | TSHR (0.68) | TSHRALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL10952722 | 0.70 | MAPK1 (0.44) | TSHRALDH1A1GAAHPGDLMNA | |
| SCHEMBL1126753 | 0.69 | TSHR (0.53) | TSHRALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL20567847 | 0.69 | TSHR (0.56) | TSHRALDH1A1SMN1; SMN2GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4494547-A | 2H-isoindolediones, their synthesis and use as radiosensitizers | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1985-01-22 | — | — | US | disclosed |