Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659373 | 0.77 | KDM4E (0.42) | PTGS1PPARGPPARDPPARAGPBAR1 | |
| SCHEMBL10738125 | 0.76 | PPARG (0.44) | PTGS1PPARGPPARDPPARAGPBAR1 | |
| SCHEMBL10661841 | 0.76 | MAPT (0.41) | PTGS1PPARGPPARDPPARAGPBAR1 | |
| SCHEMBL10655745 | 0.76 | NPC1 (0.43) | PTGS1GPBAR1MAPTMEN1KMT2A | |
| SCHEMBL10736238 | 0.75 | SLC6A9 (0.39) | PTGS1PPARGPPARDPPARAGPBAR1 | |
| SCHEMBL10657441 | 0.73 | PTGS1 (0.35) | PTGS1PPARGPPARDPPARAGPBAR1 | |
| SCHEMBL10730831 | 0.73 | FFAR4 (0.39) | PTGS1PPARGPPARDPPARAGPBAR1 | |
| SCHEMBL10659655 | 0.73 | KCNN4 (0.38) | PTGS1GPBAR1MAPT | |
| SCHEMBL10733392 | 0.72 | FFAR4 (0.39) | PTGS1PPARGPPARDPPARAGPBAR1 | |
| Hydrochloric Acid SCHEMBL10729202 | 0.71 | TP53 (0.39) | PTGS1PPARGPPARDPPARAGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4504669-A | DIURETIC | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-03-12 | — | — | US | disclosed |
| US-4427691-A | DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1984-01-24 | — | — | US | disclosed |
| EP-0058977-A1 | 1,2-Benzisoxazoloxyethylamines, their intermediates, a process for their preparation, pharmaceutical composition containing the same and their use as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-09-01 | — | — | EP | disclosed |