Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 2/20 | 0.54 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10955530 | 0.81 | EGFR (0.57) | DHODHTTBK1TTBK2EGFRKDM4E | |
| SCHEMBL15381348 | 0.80 | GPR119 (0.52) | EGFR | |
| SCHEMBL10955745 | 0.78 | TTBK1 (0.51) | TTBK1TTBK2EGFRKDM4EKDR | |
| SCHEMBL10957697 | 0.78 | EGFR (0.59) | DHODHTTBK1TTBK2EGFR | |
| SCHEMBL11010395 | 0.78 | CCNT1 (0.50) | EGFRKDM4EKDR | |
| SCHEMBL10956277 | 0.78 | EGFR (0.50) | TTBK1TTBK2EGFRKDM4EKDR | |
| SCHEMBL10958226 | 0.78 | EGFR (0.57) | ABCG2TTBK1TTBK2EGFRKDM4E | |
| SCHEMBL10960284 | 0.76 | TTBK1 (0.58) | TTBK1TTBK2SYKKDM4E | |
| Hydrochloric Acid SCHEMBL10960314 | 0.76 | EGFR (0.55) | ABCG2TTBK1TTBK2EGFRKDM4E | |
| SCHEMBL10958170 | 0.75 | MAPT (0.57) | TTBK1TTBK2CLK1EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067630-B1 | PYRIMIDINE DERIVATIVES, A PROCESS FOR PREPARING THEM AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1985-05-08 | — | — | EP | disclosed |
| US-4450162-A | Pyrimidine derivatives and a pharmaceutical composition containing them | SANKYO COMPANY, LIMITED (JP) | 1984-05-22 | — | — | US | disclosed |
| EP-0067630-A1 | Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-22 | — | — | EP | disclosed |