Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.51 |
| ▸ | PLAT | P00750 | 2/20 | 0.51 |
| ▸ | KLK8 | O60259 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | KLK2 | P20151 | 1/20 | 0.51 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 5/20 | 0.47 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.46 |
| ▸ | KYNU | Q16719 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 3/20 | 0.44 |
| ▸ | ECE1 | P42892 | 3/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957296 | 0.92 | F2 (0.59) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL10959861 | 0.91 | F2 (0.51) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL10960586 | 0.84 | MME (0.52) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL10955479 | 0.82 | F2 (0.55) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL11163829 | 0.81 | ACE (0.59) | ACE2 | |
| SCHEMBL10957871 | 0.80 | F2 (0.57) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL11173890 | 0.80 | KLK1 (0.40) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL10958284 | 0.80 | KLK1 (0.42) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL10955973 | 0.78 | KYNU (0.56) | KLK1F2PLAUPLATKLK8 | |
| SCHEMBL10957299 | 0.76 | F2 (0.59) | KLK1F2PLAUPLATKLK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063896-B1 | AMINO AND SUBSTITUTED AMINO PHOSPHINYL-ALKANOYL COMPOSITIONS | E.R. Squibb & Sons, Inc. (US) | 1985-08-14 | — | — | EP | disclosed |
| US-4416831-A | ANGIOTENSIN INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1983-11-22 | — | — | US | disclosed |
| US-4374131-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1983-02-15 | — | — | US | disclosed |
| EP-0063896-A1 | Amino and substituted amino phosphinyl-alkanoyl compositions | E.R. Squibb & Sons, Inc. (US) | 1982-11-03 | — | — | EP | disclosed |