Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.64 |
| ▸ | CDK2 | P24941 | 10/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11151222 | 0.99 | CCNA2 (0.62) | CCNA2CDK2CCNE1RAB9AHPGD | |
| SCHEMBL10957323 | 0.87 | CDK2 (0.63) | CCNA2CDK2CCNE1RAB9AHPGD | |
| SCHEMBL11010419 | 0.86 | CCNA2 (0.55) | CCNA2CDK2RAB9AHPGDLIMK1 | |
| SCHEMBL10954897 | 0.83 | ADORA2A (0.47) | CCNA2CDK2RAB9ALIMK1NPC1 | |
| SCHEMBL10957090 | 0.82 | CLK2 (0.58) | CCNA2CDK2RAB9ALIMK1NPC1 | |
| SCHEMBL10958241 | 0.82 | ALDH1A1 (0.65) | CCNA2CDK2RAB9ANPC1MAPT | |
| SCHEMBL11158198 | 0.78 | ALDH1A1 (0.56) | CCNA2CDK2CCNE1RAB9AHPGD | |
| SCHEMBL11034427 | 0.73 | CCNA2 (0.54) | CCNA2CDK2CCNE1RAB9AHPGD | |
| SCHEMBL11008126 | 0.73 | CCNA2 (0.48) | CCNA2CDK2RAB9ANPC1MAPT | |
| SCHEMBL10955560 | 0.72 | MAPT (0.44) | RAB9AHPGDNPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008047-B1 | 5(6)-(2-AMINO-5-THIAZOLOYL)BENZIMIDAZOLE-2-CARBAMIC ACID ESTERS AND THEIR SALTS, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |
| US-4386097-A | Benzimidazoles, processes for their preparation and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1983-05-31 | — | — | US | disclosed |
| US-4297365-A | Benzimidazoles and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0008047-A1 | 5(6)-(2-Amino-5-thiazoloyl)benzimidazole-2-carbamic acid esters and their salts, their preparation and use, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-02-20 | — | — | EP | disclosed |