Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.55 |
| ▸ | CDK2 | P24941 | 8/20 | 0.55 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957323 | 0.88 | CDK2 (0.63) | ALDH1A1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL11006729 | 0.88 | LMNA (0.60) | ALDH1A1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL10957665 | 0.85 | MAPT (0.57) | ALDH1A1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL10955062 | 0.84 | MAPT (0.63) | ALDH1A1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL10958069 | 0.84 | MAPT (0.56) | ALDH1A1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL10954761 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL11159298 | 0.80 | MAPT (0.63) | ALDH1A1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL10956552 | 0.78 | CCNA2 (0.64) | ALDH1A1MAPTLMNANPSR1CCNA2 | |
| Hydrochloric Acid SCHEMBL11151222 | 0.77 | CCNA2 (0.62) | ALDH1A1MAPTLMNANPSR1CCNA2 | |
| SCHEMBL11004609 | 0.77 | VCAM1 (0.51) | ALDH1A1MAPTLMNAMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4386097-A | Benzimidazoles, processes for their preparation and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1983-05-31 | — | — | US | disclosed |
| US-4297365-A | Benzimidazoles and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0008047-A1 | 5(6)-(2-Amino-5-thiazoloyl)benzimidazole-2-carbamic acid esters and their salts, their preparation and use, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-02-20 | — | — | EP | disclosed |