Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 5/20 | 0.59 |
| ▸ | MME | P08473 | 4/20 | 0.59 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
| ▸ | KLK8 | O60259 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | PLAT | P00750 | 1/20 | 0.52 |
| ▸ | KLK1 | P06870 | 1/20 | 0.52 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.50 |
| ▸ | KYNU | Q16719 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716999 | 0.91 | ECE1 (0.60) | ECE1MMECTSLCTSSKLK8 | |
| Bromide SCHEMBL1436853 | 0.90 | ECE1 (0.59) | ECE1MMECTSLCTSSKLK8 | |
| SCHEMBL10957871 | 0.87 | F2 (0.57) | ECE1MMECTSLKLK8F2 | |
| SCHEMBL7291199 | 0.87 | ECE1 (0.61) | ECE1MMEF2PLAUPLAT | |
| SCHEMBL1688341 | 0.83 | ECE1 (0.63) | ECE1MMECTSLCTSSF2 | |
| SCHEMBL10960586 | 0.82 | MME (0.52) | ECE1MMECTSLCTSSKLK8 | |
| SCHEMBL11163834 | 0.82 | MME (0.55) | ECE1MMECTSLCTSSACE2 | |
| SCHEMBL9645985 | 0.82 | ACE2 (0.68) | ECE1MMECTSLCTSSACE2 | |
| SCHEMBL10482881 | 0.81 | MME (0.56) | ECE1MMECTSLCTSSACE2 | |
| SCHEMBL10482879 | 0.81 | MME (0.56) | ECE1MMECTSLCTSSACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059597-B1 | GUANIDINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES HAVING HISTAMINE H-2 ANTAGONIST ACTIVITY | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-04-23 | — | — | EP | claimed |
| EP-0055562-B1 | CEPHALOSPORIN DERIVATIVES | ICI PHARMA (FR) | 1986-02-12 | — | — | EP | claimed |
| EP-0060094-B1 | GUANIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-22 | — | — | EP | claimed |
| EP-0067508-B1 | AMIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-10-30 | — | — | EP | claimed |
| EP-0061318-B1 | GUANIDINOHETEROCYCLIC DERIVATIVES AS HISTAMINE H-2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-10-09 | — | — | EP | claimed |
| EP-0045155-B1 | GUANIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-01-02 | — | — | EP | claimed |
| EP-0055099-B1 | PENICILLIN DERIVATIVES | ICI PHARMA (FR) | 1984-10-24 | — | — | EP | claimed |
| EP-0063896-B1 | AMINO AND SUBSTITUTED AMINO PHOSPHINYL-ALKANOYL COMPOSITIONS | E.R. Squibb & Sons, Inc. (US) | 1985-08-14 | — | — | EP | disclosed |
| US-4416831-A | ANGIOTENSIN INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1983-11-22 | — | — | US | disclosed |
| US-4374131-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1983-02-15 | — | — | US | disclosed |
| EP-0063896-A1 | Amino and substituted amino phosphinyl-alkanoyl compositions | E.R. Squibb & Sons, Inc. (US) | 1982-11-03 | — | — | EP | disclosed |