Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.68 |
| ▸ | CTSK | P43235 | 5/20 | 0.58 |
| ▸ | MME | P08473 | 1/20 | 0.58 |
| ▸ | ECE1 | P42892 | 1/20 | 0.58 |
| ▸ | CTSS | P25774 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ELANE | P08246 | 2/20 | 0.54 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15397862 | 0.92 | ACE2 (0.71) | ACE2CTSKMMEECE1CTSS | |
| SCHEMBL7291199 | 0.86 | ECE1 (0.61) | ACE2MMEECE1 | |
| SCHEMBL10746815 | 0.86 | ACE2 (0.71) | ACE2CTSKMMEECE1CTSS | |
| SCHEMBL10957871 | 0.84 | F2 (0.57) | ACE2MMEECE1CTSLELANE | |
| SCHEMBL10718516 | 0.84 | ACE2 (0.68) | ACE2CTSKMMEECE1CTSS | |
| SCHEMBL8587097 | 0.83 | ELANE (0.59) | ACE2CTSKMMEECE1CTSS | |
| SCHEMBL10958149 | 0.82 | ECE1 (0.59) | ACE2CTSKMMEECE1CTSS | |
| SCHEMBL6841176 | 0.80 | CTSK (0.67) | ACE2CTSKCTSSCTSLCTSB | |
| SCHEMBL27926954 | 0.80 | CTSK (0.67) | ACE2CTSKCTSSCTSLCTSB | |
| SCHEMBL7422252 | 0.80 | CTSK (0.67) | ACE2CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147867-A | Bactericides, (carba)penicillins | MERCK & CO., INC. (US) | 1992-09-15 | — | — | US | disclosed |
| US-5145990-A | Dehydropeptidase, carbapenicillin potentiation | MERCK & CO., INC. (US) | 1992-09-08 | — | — | US | disclosed |
| US-4962097-A | IN COMBINATION WITH A CARBAPENEM OR PENEM ANTIBIOTIC | MERCK & CO., INC. (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0366469-A2 | Phosphorus containing enzyme inhibitors | MERCK & CO. INC. (US) | 1990-05-02 | — | — | EP | disclosed |