Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095408 | 0.89 | ERN1 (0.50) | ERN1MAPTSMN1; SMN2L3MBTL1CYP2C9 | |
| SCHEMBL7046194 | 0.84 | SMN1; SMN2 (0.43) | ERN1MAPTSMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL7046356 | 0.82 | MAPT (0.41) | ERN1MAPTSMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL9120538 | 0.82 | MAPT (0.67) | MAPTSMN1; SMN2L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL768225 | 0.81 | MAPT (0.66) | ERN1MAPTSMN1; SMN2L3MBTL1CYP2C9 | |
| SCHEMBL16097345 | 0.81 | ERN1 (0.47) | ERN1MAPTSMN1; SMN2L3MBTL1CYP2C9 | |
| SCHEMBL12035865 | 0.81 | ERN1 (0.47) | ERN1MAPTSMN1; SMN2L3MBTL1CYP2C9 | |
| SCHEMBL3337249 | 0.79 | ERN1 (0.51) | ERN1L3MBTL1CYSLTR1CYSLTR2 | |
| SCHEMBL3881769 | 0.78 | CYSLTR2 (0.46) | MAPTCYP2C9CYSLTR1GRM2CYSLTR2 | |
| SCHEMBL10956480 | 0.78 | ABCB1 (0.44) | MAPTSMN1; SMN2CYP2C19NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061800-B1 | ANTI SRS-A CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | FISONS plc (GB) | 1985-08-28 | — | — | EP | disclosed |
| US-4518612-A | Naphthalene and 2-oxo-benzopyran acids and derivatives and pharamaceutical use thereof | FISONS PLC (GB) | 1985-05-21 | — | — | US | disclosed |
| US-4424231-A | Compounds | FISONS LIMITED (GB) | 1984-01-03 | — | — | US | disclosed |
| EP-0061800-A1 | Anti SRS-A carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them | FISONS plc (GB) | 1982-10-06 | — | — | EP | disclosed |