Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959657 | 0.84 | ERN1 (0.48) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL7046356 | 0.82 | MAPT (0.41) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL5071784 | 0.82 | NPC1 (0.50) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL11852626 | 0.79 | NPC1 (0.48) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL4567003 | 0.77 | FFAR4 (0.46) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL1299176 | 0.76 | CCNB2 (0.58) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL10956472 | 0.76 | LTB4R (0.39) | SMN1; SMN2MAPTL3MBTL1ERN1TDP1 | |
| SCHEMBL10956480 | 0.76 | ABCB1 (0.44) | SMN1; SMN2MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL16095408 | 0.76 | ERN1 (0.50) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL10603279 | 0.76 | BCHE (0.48) | SMN1; SMN2L3MBTL1ERN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6090836-A | DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0882029-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028137-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |