Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046194 | 0.82 | SMN1; SMN2 (0.43) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10959657 | 0.82 | ERN1 (0.48) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7044020 | 0.78 | SMN1; SMN2 (0.47) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7037967 | 0.76 | PRMT5 (0.38) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4567003 | 0.75 | FFAR4 (0.46) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10956480 | 0.74 | ABCB1 (0.44) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10956472 | 0.74 | LTB4R (0.39) | MAPTL3MBTL1SMN1; SMN2ERN1LMNA | |
| SCHEMBL16095408 | 0.74 | ERN1 (0.50) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8322535 | 0.72 | GCK (0.51) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8154576 | 0.72 | GCK (0.60) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6090836-A | DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0882029-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028137-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |