SCHEMBL1096280

SCHEMBL1096280

Cn1ncc2[nH]c(=O)[nH]c(=O)c21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 1/20 0.44
ALDH1A1 P00352 3/20 0.36
TYMP P19971 1/20 0.35
KDM4E B2RXH2 2/20 0.34
CA12 O43570 1/20 0.34
PARP1 P09874 1/20 0.34
CA9 Q16790 1/20 0.34
HPGD P15428 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CDC7 O00311 1/20 0.33
DBF4 Q9UBU7 1/20 0.33
MAPK1 P28482 2/20 0.33
CYP3A4 P08684 1/20 0.33
PMP22 Q01453 1/20 0.33
XDH P47989 1/20 0.32
CNOT7 Q9UIV1 1/20 0.31
TYRO3 Q06418 2/20 0.31
DYRK1B Q9Y463 2/20 0.31
AURKA O14965 1/20 0.31
DAPK3 O43293 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18816387 0.81 ALDH1A1 (0.34) GDAALDH1A1KDM4EHPGDMAPK1
SCHEMBL20023764 0.72 GDA (0.34) GDAALDH1A1KDM4EHPGDSMN1; SMN2
SCHEMBL23692399 0.70 KDM4C (0.32) ALDH1A1KDM4EHPGDSMN1; SMN2GSK3B
SCHEMBL24547690 0.69 ALDH1A1 (0.47) GDAALDH1A1PARP1HPGDSMN1; SMN2
SCHEMBL2193951 0.69 ALDH1A1 (0.43) GDAALDH1A1TYMPKDM4ECA12
SCHEMBL18255880 0.68 MAPK1 (0.46) ALDH1A1KDM4EHPGDMAPK1CYP3A4
SCHEMBL30577475 0.67 PARP1 (0.50) ALDH1A1KDM4ECA12PARP1CA9
SCHEMBL18362241 0.67 PARP1 (0.43) ALDH1A1KDM4EPARP1HPGDSMN1; SMN2
SCHEMBL6792539 0.66 GRIN2D (0.36) ALDH1A1KDM4EPARP1HPGDKDM4C
SCHEMBL22119141 0.66 ALDH1A1 (0.36) ALDH1A1KDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153365-B2 Oligonucleotide analogues EXIQON A/S (DK) 2012-04-10 US claimed
US-8034909-B2 Oligonucleotide analogues EXIQON A/S (DK) 2011-10-11 US claimed
US-20110245327-A1 Oligonucleotide Analogues EXIQON A/S (DK) 2011-10-06 US claimed
US-20100279895-A1 OLIGONUCLEOTIDE ANALOGUES EXIQON A/S (DK) 2010-11-04 US claimed
US-7374882-B2 Method for base sequencing and biologically active nucleic acids RIKEN (JP) 2008-05-20 US claimed
US-7034133-B2 Locked Nucleoside Analogues is a biochemical conjugate of nucleotides; as an aptamer in specific binding of antibiotics, drugs, amino acids, peptides, enzymes, saccharides, polysaccharides; heat resistance EXIQON A/S (DK) 2006-04-25 US claimed
US-6794499-B2 BICYCLIC LOCKED NUCLEOSIDE ANALOGUES EXIQON A/S (DK) 2004-09-21 US claimed
US-20040115665-A1 Method for base sequencing and biologically active nucleic acids RIKEN (JP) 2004-06-17 US claimed
US-6670461-B1 Bi-, tri, or polycyclic nucleoside analogues having a \"locked\" structure capable of forming heat resistant nucleobase specific duplexes and triplexes with single and double stranded nucleic acids. EXIQON A/S (DK) 2003-12-30 US claimed
US-6037120-A PREPARATION OF A COMPLEMENTARY OLIGONUCLEOTIDE AND HYBRIDIZING TO DNA OR RNA IN SOLUTION BENNER, STEVEN 2000-03-14 US claimed
US-5965364-A Method for selecting functional deoxyribonucleotide derivatives BENNER, STEVEN 1999-10-12 US claimed
US-5432272-A Genetic engineering BENNER, STEVEN 1995-07-11 US claimed
US-12534470-B2 DNA polymerase IIIC inhibitors and use thereof Acurx Pharmaceuticals, Inc. (US) 2026-01-27 US disclosed
US-20230250102-A1 DNA Polymerase IIIC Inhibitors and Use Thereof Acurx Pharmaceuticals, Inc. 2023-08-10 US disclosed
US-20230250102-A1 DNA Polymerase IIIC Inhibitors and Use Thereof Acurx Pharmaceuticals, Inc. 2023-08-10 US disclosed
US-20230250102-A1 DNA Polymerase IIIC Inhibitors and Use Thereof Acurx Pharmaceuticals, Inc. 2023-08-10 US disclosed
EP-1970373-A1 ALICYCLIC HETEROCYCLIC COMPOUND Mitsubishi Tanabe Pharma Corporation (JP) 2008-09-17 EP disclosed
EP-1956009-A1 AROMATIC COMPOUND Mitsubishi Tanabe Pharma Corporation (JP) 2008-08-13 EP disclosed
US-7374882-B2 Method for base sequencing and biologically active nucleic acids RIKEN (JP) 2008-05-20 US disclosed
US-20040115665-A1 Method for base sequencing and biologically active nucleic acids RIKEN (JP) 2004-06-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12534470-B2 DNA polymerase IIIC inhibitors and use thereof POLR1A, POLR2H, POLN GDA 2263/4885ALDH1A1 2357/4885TYMP 94/4885
US-20110245327-A1 Oligonucleotide Analogues POLRMT, POLM, POLN GDA 125/4885ALDH1A1 3811/4885TYMP 19/4885
US-20230250102-A1 DNA Polymerase IIIC Inhibitors and Use Thereof POLI, POLN, POLB GDA 200/4885ALDH1A1 3028/4885TYMP 28/4885
US-20100279895-A1 OLIGONUCLEOTIDE ANALOGUES POLRMT, POLM, POLN GDA 125/4885ALDH1A1 3811/4885TYMP 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.