Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28129923 | 0.87 | BACE1 (0.54) | BACE1ALDH1A1KDM4ESMN1; SMN2CLK4 | |
| Biphenyl SCHEMBL28365892 | 0.83 | NPC1 (0.44) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL5494577 | 0.79 | LCK (0.69) | BACE1ALDH1A1KDM4ESMN1; SMN2CLK4 | |
| SCHEMBL2741576 | 0.79 | LCK (0.65) | BACE1LCKKDRJAK3MAPK14 | |
| SCHEMBL15413000 | 0.76 | FGFR4 (0.53) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL27746938 | 0.76 | KDM4E (0.64) | ALDH1A1KDM4ESMN1; SMN2PIK3CAPIK3CD | |
| SCHEMBL23517028 | 0.75 | CLK2 (0.46) | BACE1ALDH1A1KDM4ESMN1; SMN2CLK4 | |
| SCHEMBL2595849 | 0.75 | HTR3A (0.50) | BACE1ALDH1A1KDM4ESMN1; SMN2DYRK1A | |
| SCHEMBL30354091 | 0.75 | HTR3A (0.50) | BACE1ALDH1A1KDM4ESMN1; SMN2DYRK1A | |
| SCHEMBL12365560 | 0.75 | TRIM58 (0.59) | BACE1LCKKDRJAK3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087337-B1 | 2-PIPERAZINYL-4-PHENYL-QUINAZOLINE DERIVATIVES WITH ANTIDEPRESSIVE PROPERTIES, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AND MEDICINES CONTAINING THEM | SANOFI S.A. (FR) | 1986-04-16 | — | — | EP | disclosed |
| EP-0079810-B1 | DERIVATIVES OF 4-PHENYL-QUINAZOLINE ACTIVE ON THE CENTRAL NERVOUS SYSTEM | SANOFI S.A. (FR) | 1986-01-22 | — | — | EP | disclosed |
| EP-0079810-A1 | Derivatives of 4-phenyl-quinazoline active on the central nervous system | SANOFI S.A. (FR) | 1983-05-25 | — | — | EP | disclosed |