Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1096404 | 1.00 | P2RX7 (0.67) | P2RX7PKMRIPK1POLBATM | |
| SCHEMBL1096783 | 0.92 | P2RX7 (0.81) | P2RX7PKMRIPK1POLBOPRK1 | |
| SCHEMBL1096780 | 0.92 | P2RX7 (0.81) | P2RX7PKMRIPK1POLBOPRK1 | |
| SCHEMBL1098202 | 0.89 | P2RX7 (0.67) | P2RX7 | |
| SCHEMBL1098200 | 0.89 | P2RX7 (0.67) | P2RX7 | |
| SCHEMBL1097737 | 0.87 | P2RX7 (0.58) | P2RX7POLBATML3MBTL1OPRK1 | |
| SCHEMBL1097740 | 0.87 | P2RX7 (0.58) | P2RX7POLBATML3MBTL1OPRK1 | |
| SCHEMBL1095651 | 0.81 | P2RX7 (0.82) | P2RX7OPRK1OPRM1 | |
| SCHEMBL1096756 | 0.81 | P2RX7 (0.82) | P2RX7L3MBTL1 | |
| SCHEMBL1097058 | 0.80 | P2RX7 (0.64) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153808-B2 | Dihydropyridone amides as P2X7 modulators | ROCHE PALO ALTO LLC (US) | 2012-04-10 | — | — | US | disclosed |
| US-20100160387-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160387-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX3, P2RX1 | P2RX7 6/4885PKM 1647/4885RIPK1 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.