Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | KDM1A | O60341 | 6/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5923778 | 1.00 | SLC18A3 (0.54) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL10964208 | 1.00 | SLC18A3 (0.54) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL10964453 | 1.00 | SLC18A3 (0.54) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL8273744 | 1.00 | SLC18A3 (0.54) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL8317532 | 0.85 | KDM1A (0.50) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL11565325 | 0.85 | KDM1A (0.50) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL11565322 | 0.85 | KDM1A (0.50) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL8471748 | 0.85 | KDM1A (0.50) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL407883 | 0.85 | KDM1A (0.50) | SLC18A3HTR2AKDM1AMAOBMAOA | |
| SCHEMBL8870050 | 0.85 | KDM1A (0.50) | SLC18A3HTR2AKDM1AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034647-B1 | 4-ARYLOXY-3-PHENYLPIPERIDINE DERIVATIVES, INTERMEDIATES, A PROCESS FOR THE PREPARATION OF SUCH COMPOUNDS AND THEIR USE AS MEDICAMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-06-05 | — | — | EP | disclosed |
| US-4424357-A | Process for preparing 4-aryloxy-3-phenylpiperidines | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1984-01-03 | — | — | US | disclosed |
| EP-0014997-B1 | 4-ARYLOXY- AND 4-ARYLTHIO-3-PHENYLPIPERIDINE DERIVATIVES, A PROCESS FOR THE PREPARATION OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-07-20 | — | — | EP | disclosed |
| US-4382141-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-05-03 | — | — | US | disclosed |
| US-4312876-A | CENTRAL NERVOUS SYSTEM | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-01-26 | — | — | US | disclosed |
| US-4302590-A | THE 4-HYDROXY DERIVATIVE; ANALGESICS, ANTIDEPRESSANTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-11-24 | — | — | US | disclosed |
| EP-0034647-A2 | 4-Aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-02 | — | — | EP | disclosed |
| EP-0014997-A1 | 4-Aryloxy- and 4-arylthio-3-phenylpiperidine derivatives, a process for the preparation of such compounds and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-09-03 | — | — | EP | disclosed |
| US-4216218-A | Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-08-05 | — | — | US | disclosed |