Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23269745 | 0.93 | NAMPT (0.38) | NAMPTCHRNB2CHRNB4CHRNA4KDM4E | |
| SCHEMBL24176436 | 0.74 | EPHX1 (0.52) | NAMPTSMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL11343123 | 0.72 | FDPS (0.48) | CHRNB2CHRNB4CHRNA4CHRNA3MMP1 | |
| SCHEMBL10272736 | 0.71 | CHRNB2 (0.44) | CHRNB2CHRNB4CHRNA4KDM4ECHRNA3 | |
| SCHEMBL497808 | 0.71 | CA12 (0.36) | NAMPTTDP1CA1CA9CA12 | |
| SCHEMBL6207217 | 0.71 | MEN1 (0.38) | NAMPTTDP1CA1CA9CA12 | |
| SCHEMBL26407830 | 0.71 | CA12 (0.32) | CHRNB2CHRNB4CHRNA4CHRNA3CA1 | |
| SCHEMBL24406166 | 0.71 | NAMPT (0.35) | NAMPTCA1CA9CA12KDM4C | |
| SCHEMBL20852590 | 0.71 | CHRNB2 (0.31) | CHRNB2CHRNB4CHRNA4CHRNA3 | |
| SCHEMBL965807 | 0.69 | NAMPT (0.37) | NAMPTCA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4546182-A | TREATMENT OF RESPIRATORY AND CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET DRACO (SE) | 1985-10-08 | — | — | US | disclosed |