Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.65 |
| ▸ | PDE1A | P54750 | 1/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.65 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 18/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288026 | 0.79 | PDE3B (1.00) | PDE2APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL10625021 | 0.76 | PDE3B (0.64) | PDE2APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL10960764 | 0.75 | MAOB (0.49) | PDE3BPDE3AMAOBPDE4APDE4B | |
| SCHEMBL10960086 | 0.74 | PDE3B (0.62) | PDE3BPDE3AMAOB | |
| SCHEMBL11022114 | 0.73 | PDE2A (0.51) | PDE2APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL8818584 | 0.70 | PDE2A (0.53) | PDE2APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL7281009 | 0.69 | PDE3B (0.55) | PDE2APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL10744142 | 0.69 | PDE3A (0.54) | PDE2APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL7321194 | 0.69 | MAOB (0.53) | MAOB | |
| SCHEMBL22288623 | 0.68 | MAOB (0.63) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508718-A | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-04-02 | — | — | US | claimed |
| EP-0149543-A1 | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-07-24 | — | — | EP | disclosed |
| US-4508718-A | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-04-02 | — | — | US | disclosed |