Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.49 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Panuramine SCHEMBL2037759 | 0.81 | MCHR1 (0.83) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| Panuramine SCHEMBL9749426 | 0.81 | MCHR1 (0.81) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| SCHEMBL9590523 | 0.80 | DRD4 (0.67) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| SCHEMBL9590597 | 0.80 | DRD4 (0.67) | DRD4MCHR1EPHX1SLC6A12SLC6A13 | |
| SCHEMBL16322087 | 0.79 | DRD4 (0.69) | DRD4EPHX1EPHX2 | |
| SCHEMBL4502456 | 0.78 | DRD4 (0.67) | DRD4EPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL8346658 | 0.78 | DRD4 (0.64) | DRD4MCHR1SLC6A12SLC6A13SMN1; SMN2 | |
| SCHEMBL10964860 | 0.77 | DRD4 (0.53) | DRD4MCHR1EPHX1SLC6A12SLC6A13 | |
| SCHEMBL10144870 | 0.77 | DRD4 (0.60) | DRD4MCHR1SLC6A12SLC6A13SMN1; SMN2 | |
| SCHEMBL13801318 | 0.77 | DRD4 (0.66) | DRD4MCHR1EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035374-B1 | PIPERIDYL - UREA, - THIOUREA AND - GUANIDINE DERIVATIVES, AND INTERMEDIATES THEREFOR, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1985-01-30 | — | — | EP | disclosed |