Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.44 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590597 | 0.87 | DRD4 (0.67) | DRD4MCHR1EPHX2SLC6A12SLC6A13 | |
| SCHEMBL10965667 | 0.77 | DRD4 (0.58) | DRD4MCHR1EPHX2SLC6A12SLC6A13 | |
| Panuramine SCHEMBL2037759 | 0.76 | MCHR1 (0.83) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| Panuramine SCHEMBL9749426 | 0.75 | MCHR1 (0.81) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| SCHEMBL9590523 | 0.74 | DRD4 (0.67) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| SCHEMBL9592555 | 0.73 | DRD4 (0.79) | DRD4MCHR1SLC6A12ALDH1A1 | |
| SCHEMBL9592126 | 0.73 | DRD4 (0.51) | DRD4MCHR1NPSR1EPHX1ALDH1A1 | |
| SCHEMBL11297107 | 0.72 | OPRM1 (0.49) | DRD4EPHX2NPSR1ALDH1A1 | |
| SCHEMBL16322087 | 0.71 | DRD4 (0.69) | DRD4EPHX2NPSR1EPHX1 | |
| SCHEMBL4502456 | 0.71 | DRD4 (0.67) | DRD4EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035374-B1 | PIPERIDYL - UREA, - THIOUREA AND - GUANIDINE DERIVATIVES, AND INTERMEDIATES THEREFOR, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1985-01-30 | — | — | EP | claimed |