Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.58 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.58 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.58 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.54 |
| ▸ | NSD2 | O96028 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18579665 | 0.82 | KDM4C (0.61) | KDM5AKDM2BKDM4CKDM5BNSD3 | |
| SCHEMBL19125499 | 0.80 | HDAC8 (0.75) | KDM5AKDM2BKDM4CKDM5BPTGS2 | |
| SCHEMBL17434351 | 0.80 | KDM2B (0.53) | KDM5AKDM2BKDM4CKDM5BPTGS2 | |
| SCHEMBL17434349 | 0.80 | HDAC8 (0.75) | KDM5AKDM2BKDM4CKDM5BPTGS2 | |
| SCHEMBL18041832 | 0.80 | TGFBR1 (0.57) | KDM5AKDM2BKDM4CKDM5BCLK4 | |
| SCHEMBL18041773 | 0.79 | TGFBR1 (0.68) | KDM5AKDM2BKDM4CKDM5BNSD2 | |
| SCHEMBL4085395 | 0.78 | MAPK14 (0.58) | KDM5AKDM2BKDM4CKDM5BMAPK14 | |
| SCHEMBL1009513 | 0.77 | NSD3 (0.83) | KDM2BKDM4CPTGS2MAPK14NSD3 | |
| SCHEMBL17596821 | 0.77 | KDM5A (0.44) | KDM5AKDM2BKDM4CKDM5BNSD2 | |
| SCHEMBL10969997 | 0.77 | PTGS2 (0.66) | PTGS2MAPK14PDE10AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102190625-A | Stilbene tumor targeted medicine Combretastatin A4 analogs | NANJING SANHOME PHARMACEUTICAL CO LTD | 2011-09-21 | — | — | CN | claimed |
| CN-102190625-B | Stilbene tumor targeted medicine Combretastatin A4 analogs | NANJING SANHOME PHARMACEUTICAL CO LTD | 2013-08-28 | — | — | CN | disclosed |
| CN-102190625-A | Stilbene tumor targeted medicine Combretastatin A4 analogs | NANJING SANHOME PHARMACEUTICAL CO LTD | 2011-09-21 | — | — | CN | disclosed |
| EP-0043788-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | disclosed |
| US-4528298-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-07-09 | — | — | US | disclosed |
| US-4503065-A | ANTIARTHRITIC, ANALGESIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| US-4402960-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | disclosed |
| US-4372964-A | ANAGESIC, ANTIARTHRITIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-02-08 | — | — | US | disclosed |
| EP-0043788-A1 | Imidazole derivatives, process for their preparation and their pharmaceutical compositions | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-01-13 | — | — | EP | disclosed |
| EP-0032113-A2 | Antiinflammatory 4,5-diaryl-alpha-(polyhaloalkyl)-1H-imidazole-2-methanols | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-07-15 | — | — | EP | disclosed |