SCHEMBL10967368

SCHEMBL10967368

CCOC(=O)C(=CNc1ncnc2cc(OC)ccc12)C(=O)OCC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.53
NPSR1 Q6W5P4 2/20 0.53
MAPT P10636 2/20 0.52
LMNA P02545 1/20 0.52
KMT2A Q03164 4/20 0.52
NPC1 O15118 2/20 0.52
CASP3 P42574 2/20 0.52
RAB9A P51151 2/20 0.52
SENP8 Q96LD8 2/20 0.52
SENP7 Q9BQF6 2/20 0.52
SENP6 Q9GZR1 2/20 0.52
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
MAPK1 P28482 1/20 0.50
CYP2C19 P33261 1/20 0.50
CSF1R P07333 1/20 0.48
EGFR P00533 6/20 0.48
GAA P10253 2/20 0.45
ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10966662 0.87 KMT2A (0.55) KDM4ENPSR1MAPTKMT2ANPC1
SCHEMBL11097903 0.85 EGFR (0.56) KDM4ENPSR1MAPTKMT2AMAPK1
SCHEMBL10970601 0.84 KDR (0.57) MAPTCYP1A2CYP3A4CYP2D6MAPK1
SCHEMBL10972030 0.83 EGFR (0.50) KDM4ENPSR1MAPTCYP1A2CYP3A4
SCHEMBL10967972 0.82 RAB9A (0.59) KDM4ENPSR1MAPTLMNAKMT2A
SCHEMBL10969276 0.81 KDM4E (0.57) KDM4ENPSR1MAPTLMNAKMT2A
SCHEMBL10967652 0.79 EGFR (0.53) KDM4ENPSR1MAPTLMNAKMT2A
SCHEMBL10970783 0.79 CYP1A2 (0.51) KDM4ENPSR1MAPTLMNAKMT2A
SCHEMBL10971593 0.79 EGFR (0.52) KDM4ENPSR1MAPTKMT2ANPC1
SCHEMBL10970750 0.77 EGFR (0.51) KDM4ENPSR1MAPTKMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4543356-A Quinazoline derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1985-09-24 US disclosed