SCHEMBL10967553

SCHEMBL10967553

CCCOC(=O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.46
FPR2 P25090 1/20 0.44
SCN9A Q15858 1/20 0.44
GAA P10253 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CYP1A1 P04798 1/20 0.43
CYP1B1 Q16678 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.42
KMT2A Q03164 2/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
LMNA P02545 1/20 0.41
MEN1 O00255 1/20 0.40
MAPK14 Q16539 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10755853 0.93 IDH1 (0.45) IDH1FPR2SCN9AGAATDP1
SCHEMBL403443 0.89 IDH1 (0.55) IDH1FPR2SCN9AGAATDP1
SCHEMBL10761100 0.89 GAA (0.47) IDH1FPR2SCN9AGAATDP1
SCHEMBL11574550 0.86 IDH1 (0.43) IDH1FPR2SCN9AGAATDP1
SCHEMBL11488521 0.86 SLC6A4 (0.46) IDH1KMT2AMEN1
SCHEMBL11555640 0.86 IDH1 (0.42) IDH1FPR2SCN9AGAATDP1
SCHEMBL11040611 0.85 L3MBTL1 (0.41) IDH1FPR2SCN9AGAATDP1
SCHEMBL11557269 0.85 GAA (0.43) IDH1FPR2SCN9AGAATDP1
SCHEMBL11573443 0.85 IDH1 (0.41) IDH1FPR2SCN9AGAATDP1
SCHEMBL11558633 0.85 MMP2 (0.46) IDH1FPR2SCN9AGAATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4531969-A Combatting growth of weeds HOECHST AKTIENGESELLSCHAFT (DE) 1985-07-30 US disclosed