Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309471 | 0.85 | KDM4E (0.51) | KDM4EHSD17B10MAOAMAOBMAPK1 | |
| SCHEMBL7706290 | 0.84 | KDM4E (0.50) | KDM4EHSD17B10MAOAMAOBMAPK1 | |
| SCHEMBL4675984 | 0.82 | MAOA (0.68) | KDM4EHSD17B10MAOAMAOBMAPK1 | |
| SCHEMBL11491653 | 0.82 | ALDH1A1 (0.43) | KDM4EHSD17B10ALDH1A1POLBRAB9A | |
| SCHEMBL5311626 | 0.82 | MAOA (0.53) | KDM4EHSD17B10MAOAMAOBMAPK1 | |
| SCHEMBL7469464 | 0.81 | MAOB (0.52) | KDM4EHSD17B10MAOAMAOBMAPK1 | |
| SCHEMBL10966875 | 0.81 | MAOB (0.49) | KDM4EHSD17B10MAOBMAPK1ALDH1A1 | |
| SCHEMBL2303899 | 0.80 | MAOA (0.51) | KDM4EHSD17B10MAOAMAOBMAPK1 | |
| SCHEMBL17842824 | 0.80 | MAOB (0.51) | KDM4EHSD17B10MAOAMAOBMAPK1 | |
| SCHEMBL931020 | 0.80 | MAOB (0.51) | KDM4EHSD17B10MAOAMAOBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029311-B1 | AMINOALKYL BENZOFURAN DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1985-01-23 | — | — | EP | disclosed |
| EP-0029311-A1 | Aminoalkyl benzofuran derivatives, their production and compositions containing them | MERCK & CO. INC. (US) | 1981-05-27 | — | — | EP | disclosed |