Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296851 | 0.83 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL12310224 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL12885924 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL18710345 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL153251 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL21580905 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2HTTKDM4EPOLB | |
| SCHEMBL8259396 | 0.81 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL22298940 | 0.81 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL17951102 | 0.81 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A | |
| SCHEMBL14874211 | 0.80 | KDM4E (0.63) | ALDH1A1SMN1; SMN2KDM4ETDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0066456-B1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND THEIR ESTERS | SMITHKLINE BECKMAN CORPORATION (US) | 1985-04-24 | — | — | EP | disclosed |
| EP-0066456-A1 | N-substituted azaheterocyclic carboxylic acids and their esters | SMITHKLINE BECKMAN CORPORATION (US) | 1982-12-08 | — | — | EP | disclosed |