Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.49 |
| ▸ | GCGR | P47871 | 7/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6484619 | 0.83 | PDE10A (0.60) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9745970 | 0.73 | PTGS1 (0.76) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| Bromide SCHEMBL11178458 | 0.71 | PTGS1 (0.60) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL14060387 | 0.70 | KDM4E (0.84) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL8309758 | 0.70 | MAPK13 (0.75) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL11396176 | 0.70 | PTGS1 (0.78) | MAPK14PTGS1PTGS2 | |
| SCHEMBL10970174 | 0.69 | PTGS1 (0.49) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL10970206 | 0.69 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL11469029 | 0.69 | KDM4E (0.73) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL11507098 | 0.69 | SMPD3 (0.41) | MAPK14PTGS1PTGS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4402960-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | claimed |
| EP-0043788-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | disclosed |
| US-4528298-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-07-09 | — | — | US | disclosed |
| US-4402960-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | disclosed |
| EP-0043788-A1 | Imidazole derivatives, process for their preparation and their pharmaceutical compositions | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-01-13 | — | — | EP | disclosed |