Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.61 |
| ▸ | GCGR | P47871 | 5/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382433 | 0.82 | KDM4E (1.00) | PTGS1PTGS2LMNAL3MBTL1KDM4E | |
| SCHEMBL11396176 | 0.82 | PTGS1 (0.78) | PTGS1PTGS2MAPK14 | |
| SCHEMBL11272419 | 0.80 | ALDH1A1 (0.66) | PTGS1PTGS2LMNAL3MBTL1KDM4E | |
| Bromide SCHEMBL11178458 | 0.80 | PTGS1 (0.60) | PTGS1PTGS2KDM4EMAPK14MAPK13 | |
| SCHEMBL3956357 | 0.80 | MAPK13 (0.74) | PTGS1PTGS2MAPK14MAPK13MAPK12 | |
| SCHEMBL9748575 | 0.78 | MAPK13 (0.83) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7041734 | 0.77 | KDM4E (0.67) | PTGS1PTGS2KDM4EHPGDMAPK14 | |
| SCHEMBL13712659 | 0.76 | MAPK14 (1.00) | PTGS1PTGS2MAPK14MAPK13MAPK12 | |
| SCHEMBL4460547 | 0.76 | MAPK14 (1.00) | PTGS1PTGS2MAPK14MAPK13MAPK12 | |
| SCHEMBL10963418 | 0.76 | MAPK14 (0.66) | PTGS1PTGS2KDM4EMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236628-B1 | INHIBITION OF THE 5-LIPOXYGENASE PATHWAY | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-02 | — | — | EP | disclosed |
| US-4780470-A | WITH 4,5-DIALKYL-2(SUBSTITUTED)IMIDAZOLE | SMITHKLINE BECKMAN CORPORATION (US) | 1988-10-25 | — | — | US | disclosed |
| US-4686231-A | 4,5-DIARYL-2-SUBSTITUTED-IMIDAZOLE | SMITHKLINE BECKMAN CORPORATION (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0008755-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-NITROIMIDAZOLES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-21 | — | — | EP | disclosed |
| EP-0011115-B1 | ANTIINFLAMMATORY 2-SUBSTITUTED-1H-PHENANTHRO(9,10-D)IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-01-20 | — | — | EP | disclosed |
| US-4251535-A | ANTIARTHRITIC AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4215135-A | Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-07-29 | — | — | US | disclosed |
| EP-0011115-A1 | Antiinflammatory 2-substituted-1H-phenanthro(9,10-d)imidazoles, their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-05-28 | — | — | EP | disclosed |
| US-4199592-A | Antiinflammatory 4,5-diaryl-2-nitroimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| US-4198421-A | ANTIARTHRITIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |
| EP-0008755-A1 | Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-03-19 | — | — | EP | disclosed |
| US-4190666-A | ANTIARTHRITIC, ANALGESIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4182769-A | ANALGESIC, ANTIARTHRITIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-01-08 | — | — | US | disclosed |
| US-4159338-A | ANTIARTHRITIC, ANALGESIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-06-26 | — | — | US | disclosed |