Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL10969833

C=CCc1c(CC)ccc(OC)c1OC.N

nearest known ligand 0.44

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
POLB P06746 2/20 0.44
KDM4E B2RXH2 1/20 0.44
HPGD P15428 1/20 0.44
PPARG P37231 1/20 0.44
PPARD Q03181 1/20 0.44
PPARA Q07869 1/20 0.44
ALOX5 P09917 4/20 0.41
GABRA1 P14867 4/20 0.41
GABRB2 P47870 4/20 0.41
CNR2 P34972 2/20 0.41
CYP3A4 P08684 2/20 0.41
ALOX15 P16050 1/20 0.41
PTGS1 P23219 2/20 0.39
AR P10275 1/20 0.37
TRPM8 Q7Z2W7 1/20 0.37
P2RX7 Q99572 1/20 0.37
MAPT P10636 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ELANE P08246 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11553227 0.85 CYP3A4 (0.45) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL11025102 0.84 POLB (0.44) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL10969347 0.83 POLB (0.43) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL11213474 0.82 HSD17B10 (0.47) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL10970024 0.81 TAAR1 (0.44) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL10964680 0.80 POLB (0.42) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL11210388 0.79 AOC3 (0.43) POLB
SCHEMBL11413187 0.78 ALDH1A1 (0.47) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL11209491 0.78 CYP3A4 (0.42) ALDH1A1POLBKDM4EHPGDPPARG
SCHEMBL2051289 0.77 ALDH1A1 (0.48) ALDH1A1POLBKDM4EHPGDPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0035881-B1 2,3,4,5,6,7-HEXAHYDRO-10-HYDROXY-2-METHYL-8-PHENYL-8H-FURO(3,2-G)-3-BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM SMITHKLINE BECKMAN CORPORATION (US) 1985-07-17 EP disclosed
EP-0036773-B1 2,3-DIHYDROBENZOFURANS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SMITHKLINE BECKMAN CORPORATION (US) 1983-02-16 EP disclosed
US-4255445-A DOPAMINERGIC ACTIVITY, RENAL VASODILATING ACTIVITY SMITHKLINE CORPORATION (US) 1981-03-10 US disclosed
US-4254140-A USED FOR CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENT SMITHKLINE CORPORATION (US) 1981-03-03 US disclosed