Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11213474 | 0.81 | HSD17B10 (0.47) | CYP3A4POLBTDP1PTGS1NPSR1 | |
| Ammonia Solution, Strong SCHEMBL10969833 | 0.78 | ALDH1A1 (0.44) | CYP3A4POLBTDP1PTGS1ALDH1A1 | |
| SCHEMBL11210388 | 0.78 | AOC3 (0.43) | POLBAOC3 | |
| SCHEMBL11025102 | 0.72 | POLB (0.44) | CYP3A4POLBTDP1PTGS1ALDH1A1 | |
| SCHEMBL10969347 | 0.71 | POLB (0.43) | CYP3A4POLBPTGS1ALDH1A1KDM4E | |
| SCHEMBL10536230 | 0.71 | PTGS1 (0.62) | CYP3A4TSHRPOLBTDP1PTGS1 | |
| SCHEMBL11553227 | 0.70 | CYP3A4 (0.45) | CYP3A4TSHRPOLBTDP1PTGS1 | |
| SCHEMBL6430390 | 0.70 | TDP1 (0.55) | CYP3A4POLBTDP1PTGS1ALDH1A1 | |
| SCHEMBL10970024 | 0.70 | TAAR1 (0.44) | CYP3A4CYP1A2POLBALDH1A1KDM4E | |
| SCHEMBL28626652 | 0.69 | MAPT (0.43) | CYP3A4POLBTDP1PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036773-B1 | 2,3-DIHYDROBENZOFURANS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0036773-A1 | 2,3-Dihydrobenzofurans, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1981-09-30 | — | — | EP | disclosed |
| US-4254140-A | USED FOR CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENT | SMITHKLINE CORPORATION (US) | 1981-03-03 | — | — | US | disclosed |